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UPDATE 1-US FDA advisers skeptical on Teva Parkinson’s drug


* First to seek approval as delaying disease progressionBy Alina SelyukhSILVER SPRING, Md., Oct 17 (Reuters) - U.S. health advisers on Monday voiced skepticism that Teva Pharmaceutical Industries Ltd’s Parkinson’s drug Azilect actually slows the progression of the incurable disease.Advisers to the Food and Drug Administration, following the note struck by FDA researchers last week, voted unanimously to say that data from Teva’s latest trial were unconvincing of Azilect’s ability to delay the clinical progression of Parkinson’s.Azilect, generically known as rasagiline and already approved as a Parkinson’s therapy, is the first drug to seek FDA’s approval as a medicine that affects the course of the neurogenetic disorder instead of merely masking its symptoms.”This is really going to be the flagship… and we have to be very solid in this and set a very high standard,” said Dr. Robert Clancy, one of the panel members and a neurology professor at the Children’s Hospital of Philadelphia.”If we’re wishy-washy with this, then the next thing that comes around is going to be expecting that being close is good enough. And this is close, but it’s not good enough.”Azilect, which Israel-based Teva markets alongside Danish partner Lundbeck in several countries, already has FDA approval to treat symptoms of the neurological disorder, such as trembling limbs, stiffness, slow movement and impaired balance. Teva is seeking an expansion of Azilect’s label.In Teva’s latest trial, Parkinson’s appeared to deteriorate more slowly in patients who started taking Azilect earlier than in those who began later. But while the 1 milligram (mg) dose appeared to slow the progression, the 2 mg dose did not, overshadowing the results of the 1 mg trial under review.

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Irish credit unions face 1 bln euro shortfall


Dublin has pledged to tighten up governance of credit unions as part of its EU-IMF bailout, and an interim report by the Commission on Credit Unions said the government may need to intervene to deal with some clubs facing financial difficulties.The Commission, whose report will influence new legislation set to be published before the end of the year, said a stabilisation fund, financed by credit unions, should be created to provide capital to “viable” credit unions in financial difficulty.Some credit unions lent aggressively during the “Celtic Tiger” property bubble and the Commission said arrears had nearly doubled to 18.7 percent of the sector’s gross loan book this year compared with 9.85 percent in 2009.Provisioning for bad debts by credit unions have more than trebled to 738.4 million euros over the past five years, but that is still 1 billion euros short of total arrears, the report said.

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UPDATE 1-RIM says BlackBerry services have improved significantly


Oct 13 (Reuters) - Research In Motion’s BlackBerry services have improved significantly across Europe, the Middle East, Africa and India, the company said on Thursday, after a three-day global service outage hit millions of its customers.”Service levels are also progressing well in the U.S., Canada and Latin America and we are seeing increased traffic throughput on most services, although there are still some delays and services levels may still vary amongst customers,” RIM said in an update on its website.The company, however, said it cannot give an estimated time for the full recovery of services around the world.On Wednesday, the company said it would eventually deliver all delayed email and instant messages to customers in five continents affected by the outage, but later told some of its corporate clients that it may not clear the huge backlog of messages until Thursday morning on the U.S. East Coast.It apologized to customers in a statement on its Website and on its Facebook page.The outage, the worst in about two years, adds to RIM’s mounting problems, which include rising dissatisfaction with its co-chief executives and the company’s inability to catch up with nimbler rivals like Apple .

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Robert Galvin, long-time CEO of Motorola, dies


Oct 12 (Reuters) - Robert Galvin, 89 — a long-time chief executive of Motorola, the telecommunications company that created the first cellphone — has died.Galvin, who was CEO of Motorola for almost three decades, passed away during the night of Oct 11, according to a statement from his family on Wednesday.Robert Galvin took the reins of the company in 1959 after the death of his father, Motorola founder Paul Galvin. At that point Motorola had annual revenue of about $290 million, which it derived primarily from North America.By the time Galvin stepped down as Motorola’s chairman in 1990, the company’s annual sales had grown to $10.8 billion. He had relinquished the post of CEO in 1986.It was under his leadership that Motorola expanded in overseas markets and in 1973 unveiled the first prototype cellphone.Robert’s son Chris Galvin became Motorola CEO in 1997, but Robert stayed on the Motorola board until 2001.Motorola Inc, was split in two in January this year under pressure from investors including Carl Icahn as the company’s storied cellphone division had been losing ground to rivals for years. The split formed Motorola Solutions and Motorola Mobility , which is being sold to Google Inc .Motorola Solutions CEO Greg Brown said Robert Galvin was the CEO that made the biggest impact on Motorola’s history.”He was a global thinker. He saw around corners. He put an extraordinary emphasis on innovation,” Brown told Reuters.Galvin was also a very personable leader and “remembered people’s names.” “He knew about their families. He knew what they did,” Brown said.

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Europe highlights urgency for new U.S. swaps rules


* Investors embrace clearing in boon for CME, LCH, ICE* CFTC inundated with thousands of industry lettersBy Jonathan Spicer and Ann SaphirCHICAGO, Oct 12 (Reuters) - Europe’s debt problems are increasing anxiety about the vulnerability of global markets because too many new U.S. derivatives rules intended to prevent a repeat of the 2008 crisis have yet to be defined.Investors have responded in recent months by embracing the clearing of swaps, essentially beating regulators to the punch, to protect themselves in volatile markets.Clearing allows investors to avoid the credit risk of trading with banks that appear newly vulnerable amid Europe’s debt crisis. In 2008-2009 banks’ worries about the health of their trading partners resulted in a widespread freezing of credit, which nearly sank the global economy.Executives at a futures industry conference here urged regulators to speedily adopt rules for trading and clearing in the over-the-counter swaps market. The longer we wait, they said, the more dangerous it becomes.”If we were the five senior staff on the Titanic, I’d like to think we wouldn’t be standing back, looking at the safety boats and thinking about whether we can design them better,” CME Group Inc chief executive Craig Donohue said at the Futures Industry Association.”We’d be thinking about how to get people on the boats and get them to safety, and maybe we can improve on that in the future,” he said.It has been three years since a U.S. financial crisis sent the global economy into a tailspin, and more than a year since lawmakers passed a bill designed to prevent a new crisis from taking down the financial system in similar fashion. Regulators are scrambling to finish writing the rules.Now, with Europe’s debt crisis showing some of the same signs as the United States’ meltdown, investors have rushed into clearing credit and interest rate swaps, a boon in volatile markets for companies like CME and Europe’s LCH.Clearnet.The Commodity Futures Trading Commission, which must make final about 50 new rules under the Dodd-Frank law, has struggled to keep up with the rule-making process, having finished only about a dozen of the rules.Several key rules, including capital and margin requirements, will be pushed into the first quarter of 2012, putting the agency well behind a July 2011 deadline Congress had set.Regulators have benefited from public meetings that provided input for the rules-writing, said CFTC Chairman Gary Gensler. “But the American public needs us to move forward and get the job done and finish these rules,” he told reporters.”The crisis emanating from Europe reminds us that the public is still unprotected.“‘FISH OR CUT BAIT’Investor appetite for CME’s cleared swaps soared last month, with trading in credit default and interest rate swaps rising to $42 billion in September, from less than $1 billion about a month earlier.CME’s futures business has also benefited, as swaps users seek safer alternatives to their bilateral dealings with banks. Asset managers are increasingly shifting their trades to CME, doubling their use of CME’s short-term interest rate futures in the past year for instance, and trading in currency futures rose to records in September as investors sought safety through clearing.”The trend is there,” said Jeffrey Sprecher, chief executive of IntercontinentalExchange Inc , which began clearing CDS in early 2009 and saw an 11 percent jump in credit-related revenues from the second to the third quarter of this year.”It’s obviously a very complicated global environment right now for global exchange risk, and you are seeing a migration towards futures more than the OTC market.”Despite delays by the CFTC and other agencies in defining the Dodd-Frank rules, the expectation that they will eventually come into force has allowed investors to begin clearing products they never had before.In a global market of some $480 trillion in clearable interest rate swaps, an estimated $180 trillion has yet to be cleared.Yet some, including Donohue and Sprecher, cautioned in interviews that it was important the CFTC takes the time to sift through the thousands of comment letters and get the rules right. “I think it’s well intentioned,” Sprecher said.There is also the real threat of lawsuits from the industry once the rules — from limits on excessive speculation to real-time reporting of trades to end-user exemptions — are formally adopted.But based on interviews with several traders and industry executives, the euro zone crisis is giving a new urgency to the need to define how exactly regulators want to safeguard the market.”Let’s fish or cut bait,” said Chris Hehmeyer, chief executive of Chicago-based proprietary trading firm HTG Capital Partners. “It’s time for them to go ahead and get the definitions out there so that we can get on with it.”